Custom Purification Services

TriAltus’ custom protein production service offers research labs an extension of their in-house teams, streamlining research and ensuring optimal outcomes. Our custom expression and purification team can deliver a clone of the desired DNA into an expression vector, protein expression of the desired expression construct and protein purification via our proprietary CLīM technology. We partner with customers at every stage of the discovery and development process to design and generate proteins that support their projects from initial research to clinical application.

Advantages of our CLīM™ protein expression and purification services

CL7's ultra-high affinity to the Im7 ligand means that purification often only takes a single chromatography step. This saves time, requires fewer reagents, and lowers costs. The salt-independent affinity allows for high salt washes to remove impurities early on, resulting in an ultra-high purity product (>99%). CL7 may also improve the solubility of certain proteins which can help to avoid inclusion bodies and subsequent refolding steps. The CL7 tag is cleaved to elute the target protein using PSC P, SUMO P, or another protease present in your vector.

Purifying challenging proteins

The CLīM™ system has a track record of purifying difficult proteins including: multi-subunit, DNA/RNA-binding, membrane, toxic, and biosimilars. If you are struggling to purify a protein, let our expert team of scientists take you from failure to success. 

“We contacted TriAltus for purification of a challenging protein after an unsuccessful campaign with another CRO. In under three months from our initial discussions, TriAltus provided us with high quality protein, enabling us to expand upon our discovery programs.”
Peter Sampson, PhD
Vice President, R&D 

 

Quotations and ordering

Request a quote by filling out the form below with details about your proposed purification project. Include information such as: protein name, DNA or protein sequence, desired amount in mg or cell culture in L, purity, and intended applications. Each project is unique and will be reviewed on a case-by-case basis.