Custom Protein Purification Services
Advantages of our CL7 protein expression and purification services
CL7's ultra-high affinity to the Im7 ligand means that purification often only takes 1 chromatography step. This saves time, reagents, and costs compared to other tag systems. The affinity between CL7 and Im7 is also salt-independent, allowing for high salt washes to remove impurities early and resulting in an ultra-high purity product (>99%). CL7 may also improve the solubility of certain proteins which can help to avoid inclusion bodies and subsequent refolding steps. The CL7 tag will be cleaved to elute the target protein using PSCP, SUMOP, or another protease present in your vector.
Purifying challenging proteins
The CL7/Im7 system has a track record of purifying difficult proteins including: multi-subunit, DNA/RNA-binding, membrane, toxic, and biosimilars. If you are struggling to purify a protein, let our expert team of scientists take you from failure to success.
Quotations and ordering
Request a quote by filling out the form below with details about your proposed purification project. Include information such as: protein name, DNA or protein sequence, desired amount in mg or cell culture in L, purity, and intended applications. Each project is unique and will be reviewed on a case-by-case basis.